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Contact Information
Photo of Kevin Claffey, Ph.D. Kevin Claffey, Ph.D.
Center for Vascular Biology
University of Connecticut Health Center
263 Farmington Avenue
Farmington, CT 06030-3501

Phone: 860-679-8713
Fax: 860-679-1201
Email: claffey@nso2.uchc.edu

Claffey Lab

 

Lab Members
Kevin Claffey, Ph.D.
Principle Investigator
Email: claffey@nso2.uchc.edu
Phone: 860-679-8713

Daniel Kita
Postdoctoral Fellow
Email: kita@uchc.edu
Phone: 860-679-8716

Stavros Kopsiaftis
Graduate Student
Email: skopsiaftis@student.uchc.edu
Phone: 860-679-8716
Charan Devarakonda
Graduate Student
Email: devarakonda@student.uchc.edu
Phone: 860-679-8716

Katie Sullivan
Graduate Student
Email: kasullivan@student.uchc.edu
Phone: 860-679-8716


 
 
 
 

Research Interests

Mechanisms of tumor angiogenesis mediated by hypoxia-induced vascular endothelial growth factor expression. Tumor cell regulation of VEGF transcriptional, post-transcriptional and translation under hypoxia. Cellular mRNA binding proteins facilitating VEGF expression. Tumor microenvironmental factors that modulate the balance between positive and negative angiogenic factors.

Role of membrane-type matrix metalloproteinases in breast cancer invasion and metastasis. Control of MT-MMP gene expression by tumor microenvironments mediated by cytokine, hypoxia and metabolic byproducts. MT-MMP activation cascades regulated by post-translational mechanisms.

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Research Projects
  • Identification of mRNA binding proteins that regulate VEGF mRNA stability under hypoxia. Determination of mRNA binding protein expression profiles in tumor cells with differential sensitivities to hypoxia with respect to VEGF expression. Defining signaling mechanisms which control the cellular distribution and activity of VEGF mRNA binding proteins activated under hypoxic conditions.
  • Evaluation of breast cancer molecular mechanisms controlling MT1-MMP expression. These include estrogen receptor expression, genomic methylation, transcription factor expression and activation, signal transduction pathways and loss of tumor suppressor activity.
  • Clinical translational breast, melanoma and colon cancer projects characterizing patient-specific immune response to tumor. Molecular characterization of self-reactive antigens reflected by local lymph node activation.

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Lab Methods

The following methods are used by our lab:

  • Histological Methods
  • In Vivo Angiogenesis using Matrigel Implants
  • In Vivo Microvascular Permeability Assays
  • Production of Chicken IgY Polyclonal Antibodies

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Postdoctoral Position

Postdoctoral Fellow in Translational Breast Cancer Research

The University of Connecticut Health Center seeks a motivated post-doctoral fellow to develop a unique clinical-translational research interface in the Departments of Cell Biology and the Neag Comprehensive Cancer Center. Fellow will be responsible for integrated research with multiple investigators in the Women's Cancer Consortium. Areas of investigation may include; cancer-initiating/stem cells, Next-Gen sequencing and molecular profiling, experimental models of tumor dormancy and recurrence, and dietary and metabolic factors influencing breast cancer invasion, metastasis and progression. Exciting projects evaluating patient-derived antibodies and human monoclonal cell lines also present a unique opportunity for high-impact cancer research. Candidate should have a Ph.D. or M.D./Ph.D. with experience in molecular and mechanistic cancer research or in a translational research environment. The UConn Health Center is located in the picturesque Farmington Valley in with regional access to New York, Boston and Northern New England.

Applicants should provide a cover letter of interest and CV with contact information for three references to:

Dr. Kevin Claffey
Department of Cell Biology
Center for Vascular Biology
University of Connecticut Health Center
263 Farmington Avenue
Farmington, CT 06030-3501
Email: claffey@nso2.uchc.edu

Digital format/email preferred.

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