Research Interests
Mechanisms of tumor angiogenesis mediated by hypoxia-induced vascular endothelial growth factor expression. Tumor cell regulation of VEGF transcriptional, post-transcriptional and translation under hypoxia. Cellular mRNA binding proteins facilitating VEGF expression. Tumor microenvironmental factors that modulate the balance between positive and negative angiogenic factors.
Role of membrane-type matrix metalloproteinases in breast cancer invasion and metastasis. Control of MT-MMP gene expression by tumor microenvironments mediated by cytokine, hypoxia and metabolic byproducts. MT-MMP activation cascades regulated by post-translational mechanisms.
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