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Contact Information
Guo-Hua Fong, Ph.D.
Center for Vascular Biology
University of Connecticut Health Center
263 Farmington Avenue
Farmington, CT 06030-3501

Phone: 860-679-2373
Fax: 860-679-1201
Email: fong@nso2.uchc.edu

Fong Lab

 

Lab Members
Guo-Hua Fong
Principle Investigator
Email: fong@nso2.uchc.edu
Phone: 860-679-2373

Li-Juan Duan
Research Associate
Email: duan@neuron.uchc.edu
Phone: 860-679-4482

 
Research Interests

Project 1. The Vascular system as a target for type 2 diabetes treatment. Type 2 diabetes has reached endemic levels, and leads to serious consequences such as heart attack, renal failure, blindness, amputation, and death. In spite decades of research, an effective treatment is still lacking. An important contributing factor to the devastating consequences of diabetes is loss and/or dysfunction of blood vessels in multiple tissues and organs. While vascular damages are traditionally considered results of diabetes, we propose that they also contribute to the progression of the disease. One of our objectives is to investigate how the vascular system contributes to the progression of diabetes and develop novel therapies to control this process.

Project 2. Mechanisms of vascular development. When blood vessels first form, they generally exist in a honeycomb pattern consisting of uniformly sized microvessels. To assume proper physiological functions, newly formed microvessels undergo extensive reorganization to form a tree-like hierarchical structure with clear distinctions of large trunks and progressively smaller branches. Very little is known about how this process is regulated, but yet such knowledge may be critical to the success of angiogenesis therapy. We are using the mouse retina as a model system to investigate the molecular and cellular mechanisms underlying this process.

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Lab Methods

Manipulation of human induced pluripotent stem cells, genetic modification of mice, lentiviral vector-mediated overexpression and knockdown in mice, confocal imaging, microvascular surgery, laser Doppler imaging, conventional molecular biology and biochemistry, cell culture, and immunohistochemistry.

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