Guo-Hua Fong, Ph.D.
Center for Vascular Biology
University of Connecticut Health Center
263 Farmington Avenue
Farmington, CT 06030-3501
Project 1. The Vascular
system as a target for type 2 diabetes treatment. Type 2
diabetes has reached endemic levels, and leads to serious
consequences such as heart attack, renal failure, blindness,
amputation, and death. In spite decades of research, an
effective treatment is still lacking. An important
contributing factor to the devastating consequences of
diabetes is loss and/or dysfunction of blood vessels in
multiple tissues and organs. While vascular damages are
traditionally considered results of diabetes, we propose
that they also contribute to the progression of the disease.
One of our objectives is to investigate how the vascular
system contributes to the progression of diabetes and
develop novel therapies to control this process.
Project 2. Mechanisms of
vascular development. When blood vessels first form, they
generally exist in a honeycomb pattern consisting of
uniformly sized microvessels. To assume proper physiological
functions, newly formed microvessels undergo extensive
reorganization to form a tree-like hierarchical structure
with clear distinctions of large trunks and progressively
smaller branches. Very little is known about how this
process is regulated, but yet such knowledge may be critical
to the success of angiogenesis therapy. We are using the
mouse retina as a model system to investigate the molecular
and cellular mechanisms underlying this process.
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Manipulation of human
induced pluripotent stem cells, genetic modification of
mice, lentiviral vector-mediated overexpression and
knockdown in mice, confocal imaging, microvascular surgery,
laser Doppler imaging, conventional molecular biology and
biochemistry, cell culture, and immunohistochemistry.
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