Contact Information
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Timothy Hla, Ph.D.
Center for Vascular Biology
University of Connecticut Health Center
263 Farmington Avenue
Farmington, CT 06030-3501
Phone: 860-679-4128
Fax: 860-679-1201
Email: hla@nso2.uchc.edu |
Hla Lab
Molecular mechanisms of angiogenesis, G-protein-coupled
receptor signaling, Cyclooxygenase (Cox-2) and cancer, lipid
mediators.
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Research in this laboratory is focused on two
immediate-early genes, Cox-2 and EDG-1, that are induced
during angiogenesis, also known as new vessel formation.
Cox-2 is an enzyme that catalyzes the formation of
prostaglandins. We are investigating the mechanisms by which
Cox-2 mRNA is stabilized and how enhanced Cox-2 expression
regulates tumorigenesis. EDG-1 is a G-protein-coupled
receptor for sphingosine 1-phosphate, a bioactive lipid
secreted by platelets. We are studying how this receptor
regulates specific signaling pathways to induce endothelial
cell migration and morphogenesis into capillary-like tubes.
These efforts may provide new insights to how vessels grow
in normal conditions as well as during solid tumor growth.
- Signal transduction of sphingosine 1-phosphate receptors
(EDG receptors)
- Role of EDG receptors in vascular biology, angiogenesis and
cancer
- Sphingosine kinases in angiogenesis and cancer
- Cyclooxygenase-2, angiogenesis and cancer
- Bioactive lipid signal transduction and biology
- Regulation of COX-2 gene expression
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